Take a look at the extraordinary talent, of the three founders of PLoS, Harold E. Varmus MD [Nobel prize winner] and Patrick O. Brown MD, PhD. And Michael B. Eisen PhD. Also, look at the impressive credentials of the Board of Directors of PLoS. An article, published by PLoS is at the end of this list.

Harold E. Varmus

varmus_200x273.jpgHarold Varmus, former director of the National Institutes of Health (NIH) and co-recipient of a Nobel prize for studies of the genetic basis of cancer, currently serves as the president and chief executive officer of the Memorial Sloan-Kettering Cancer Center in New York City. A native of Freeport, Long Island, Varmus majored in English literature at Amherst College and earned a master’s degree in English at Harvard University. A graduate of Columbia University’s College of Physicians and Surgeons, he worked as a medical student in a hospital in India and served on the medical house staff at Columbia-Presbyterian Hospital. His scientific training occurred first as a Public Health Service officer at the NIH, where he studied bacterial gene expression with Ira Pastan, and then as a post-doctoral fellow with J. Michael Bishop at the University of California, San Francisco (UCSF). Much of his scientific work was conducted during 23 years as a faculty member at UCSF, where he, Bishop, and their co-workers demonstrated the cellular origins of the oncogene of a chicken retrovirus. For this work, Bishop and Varmus received the 1989 Nobel Prize in Physiology or Medicine. In 1993, Varmus was named by President Bill Clinton to serve as the director of the NIH, a position he held until his appointment as CEO of the Memorial Sloan-Kettering Cancer Center. Varmus is married to Constance Casey, a journalist and horticulturist; their two sons, Jacob and Christopher, also live in New York City.

Patrick O. Brown

brown_100x137.jpgPatrick O. Brown was born in Washington, D.C., in 1954, and grew up in Northern Virginia; Paris, France; and Taipei, Taiwan. In 1972, he entered the University of Chicago, finally emerging nearly a decade later with a B.A., M.D., and Ph.D. His thesis work, with Nick Cozzarelli, investigated the basic molecular mechanisms of DNA topoisomerases. Brown completed residency training in pediatrics in 1985, at Chicago’s Children’s Memorial Hospital. In a post-doctoral fellowship at the University of California, San Francisco, with J. Michael Bishop and Harold Varmus, he characterized the mechanism by which retroviruses, such as HIV, incorporate their genes into the genomes of their hosts. In 1988, he joined the Howard Hughes Medical Institute and Stanford University School of Medicine, where he is currently a professor in the department of biochemistry. His current research activities include systematic studies of global gene expression programs and their regulation; the use of DNA microarrays and other “genomic” approaches to explore fundamental questions in cell biology, physiology, and development; and the development and application of new high-dimensional molecular profiling methods for detection and diagnosis of disease. Brown is married to Sue Klapholz, M.D., Ph.D., with three children: Zach, Ariel, and Isaac.

Michael B. Eisen

eisen_100x137.jpgMichael B. Eisen is a computational and evolutionary biologist at the University of California at Berkeley and the Ernest Orlando Lawrence Berkeley National Laboratory, and an ardent advocate for the free flow of scientific methods, data, and knowledge. He received his undergraduate degree in mathematics (with extensive side studies in ecology and evolutionary biology) from Harvard College in 1989. He received a Ph.D. in biophysics from Harvard University in 1996 for his doctoral research on influenza virus proteins structure and function. After a summer working as a play-by-play announcer for the Columbia Mules (a minor league baseball team in Columbia, Tennessee), he joined the laboratories of Patrick O. Brown and David Botstein at Stanford as a postdoctoral fellow. While at Stanford, Eisen developed methods and software for the analysis of data from genome-wide expression studies. In 2000, he moved to Berkeley, where he runs his own lab studying how regulatory information is encoded in genome sequences and the role that variation in regulatory sequences has played in evolution. He is a 2001 Pew Biomedical Scholar and received a 2004 Presidential Early Career Award for Scientists and Engineers.

PLoS Board of Directors

Harold E. Varmus, PLoS Co-founder and Chairman of the Board
President & Chief Executive,
Memorial Sloan-Kettering Cancer Center

Patrick O. Brown, PLoS Co-founder
Stanford University School of Medicine
Howard Hughes Medical Institute

Michael B. Eisen, PLoS Co-founder
Assistant Professor of Genetics, Genomics and Development, Department of Molecular and Cell Biology
University of California, Berkeley

Brian Druker
Investigator, Howard Hughes Medical Institute
JELD-WEN Chair of Leukemia Research & Professor of Medicine
Oregon Health & Science University Cancer Institute

Paul Ginsparg
Professor of Physics and Computing and Information Science
Cornell University, Ithaca, NY

Allan C. Golston
President, U.S. Program
Bill & Melinda Gates Foundation, Seattle, WA

Lawrence Lessig
Professor, Stanford Law School, Palo Alto, CA
CEO, Creative Commons
Fellow, Academy of Arts and Sciences

Don Listwin
Founder, Canary Foundation

Elizabeth Marincola
President, Science Service
Publisher, Science News

Richard Smith
Chief Executive European arm of UnitedHealth Group
Visiting Professor, London School of Hygiene & Tropical Medicine
Former Chief Executive & Editor of BMJ

Rosalind L. Smyth
Brough Professor of Paediatric Medicine and Head of the Division of Child Health at University of Liverpool

Marty Tenenbaum
Chairman and Founder of CommerceNet

Tom Unterman
Managing Partner, Rustic Canyon Partners

Beth Weil
Head of the Marian Koshland Bioscience and Natural Resources Library
University of California at Berkeley

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