More Than 1 in 20 U.S. Children Have Dizziness/Balance
Previous estimates of dizziness and balance problems in children have ranged from 5-18% and have been based on limited, foreign, population-based studies. According to a study published online in The Journal of Pediatrics (27 January 2016), to better understand the prevalence of these problems among U.S. children, data were analyzed data from the Child Balance Supplement to the 2012 National Health Interview Survey (NHIS). The NHIS is an annual survey conducted by the National Center for Health Statistics (NCHS) at the Centers for Disease Control and Prevention (CDC). The survey uses personal household interviews to gather information about a range of health topics. The Child Balance Supplement was included in 2012 and was the first large-scale supplement added to the NHIS survey to assess dizziness and balance problems among children.
For the study, the authors analyzed data on nearly 11,000 children, ages 3 to 17, based on parents’ responses to the survey. Parents were asked if in the past year, their children had been bothered by symptoms of dizziness or balance problems such as vertigo, poor balance/unsteadiness when standing up, clumsiness/poor coordination, frequent falls, fainting or light-headedness, or other dizziness and balance symptoms. Results show that more than 1 in 20 (nearly 3.3 million) children between the ages of 3 and 17 have a dizziness or balance problem. Prevalence increases with age, with 7.5% of children ages 15-17 and 6.0% of children ages 12-14 having any dizziness or balance problem, compared with 3.6% of children ages 6-8 and 4.1% of children ages 3-5. The study also found that girls have a higher prevalence of dizziness and balance problems compared to boys, 5.7% and 5.0%, respectively. In addition, non-Hispanic white children have an increased prevalence of dizziness and balance problems (6.1%) compared with Hispanic (4.6%) and non-Hispanic black (4.3%) children.
The authors report that:
1. Among children with dizziness and balance problems, 46.0% of parents reported that the children had poor coordination; 35.1% reported light-headedness; 30.9% had poor balance; 29.0% had vertigo; 25.0% reported frequent falls; and 8.5% had other dizziness and balance problems.
2. Parents reported moderate or serious difficulties in 18.6% of children with dizziness and balance problems.
3. Overall, 36.0% of children with dizziness and balance problems were seen by a health professional and 29.9% received treatment. Of those whose parents reported moderate or serious difficulties with dizziness and balance problems, 71.6% were seen by a health professional, and 62.4% were treated.
The authors also found that only one-third, or 32.8%, of parents with a child with a dizziness or balance problem reported having received a diagnosis of an underlying condition. The percentage of children diagnosed rose to 59.6% among children whose parents reported they had moderate to serious difficulties with dizziness and balance problems. Reported causes included neurological problems; ear infections; head or neck injuries or concussions; developmental motor coordination disorder; genetic causes; metabolic problems such as hypoglycemia; prescription medication or drugs; severe headaches or migraines; malformation of the ear; and vision problems.
Children with any reported difficulty hearing were two times more likely to have dizziness or balance problems compared with children who had normal hearing. Other risk factors associated with dizziness and balance problems included impairments that limit a child’s ability to crawl, walk, run or play; frequent headaches or migraines; certain developmental delays; a history of seizures in the past 12 months; stuttering/stammering; and anemia during the last 12 months. The analysis also revealed gender-specific risk factors. For example, attention deficit hyperactivity disorder, attention deficit disorder, and stuttering were linked to dizziness and balance problems in boys, while anemia, hearing difficulties, and respiratory allergies were associated with the condition in girls. Girls with dizziness and balance problems also reported having more headaches and migraines compared to boys with dizziness and balance problems.
According to the authors, the findings are consistent with the limited prevalence data in other countries, and provide much-needed baseline estimates of dizziness and balance problems in U.S. children, and that dizziness and balance problems in children continue to be an understudied area, and we hope that this analysis leads to a better understanding of the scope and risk factors associated with these issues.
FDA Approves First Drug to Show Survival Benefit in Liposarcoma
Soft tissue sarcoma (STS) is a disease in which cancer cells form in the soft tissues of the body, including the muscles, tendons, fat, blood vessels, lymph vessels, nerves and tissues around joints. Liposarcoma is a specific type of STS that occurs in fat cells and can form almost anywhere in the body, but is most common in the head, neck, arms, legs, trunk and abdomen. In 2014, an estimated 12,000 cases of STS were diagnosed in the US, according to the National Cancer Institute.
The FDA has approved Halaven (eribulin mesylate), a type of chemotherapy, for the treatment of liposarcoma that cannot be removed by surgery or is advanced (metastatic). This treatment is approved for patients who received prior chemotherapy that contained an anthracycline drug. The efficacy and safety of Halaven were evaluated in 143 clinical trial participants with advanced liposarcoma that was unresectable or had spread to nearby lymph nodes (locally advanced) or other parts of the body (metastatic), and who had been treated with chemotherapy. Participants were treated with either Halaven or another chemotherapy drug called dacarbazine until their disease spread or until they were no longer able to tolerate the side effects of treatment. The study was designed to measure the length of time from the start of treatment until a patient’s death (overall survival). Results showed that the median overall survival for patients with liposarcoma receiving Halaven was 15.6 months compared to 8.4 months for those who received dacarbazine.
The most common side effects among participants treated with Halaven were fatigue, nausea, hair loss (alopecia), constipation, certain nerve damage causing weakness or numbness in the hands and feet (peripheral neuropathy), abdominal pain and fever (pyrexia). Halaven may also cause low levels of infection-fighting white blood cells (neutropenia) or decreased levels of potassium or calcium. Serious side effects from treatment with Halaven may include a decrease in white blood cell count, which can increase the risk of serious infections that could lead to death; numbness, tingling or burning in the hands and feet (neuropathy); harm to a developing fetus; as well as changes in heartbeat (QTc prolongation), that may also lead to death.
The FDA granted the Halaven application priority review status, intended to facilitate and expedite the development and review of certain drugs in light of their potential to benefit patients with serious or life-threatening conditions. Halaven also received orphan drug designation, which provides incentives such as tax credits, user fee waivers, and eligibility for exclusivity to assist and encourage the development of drugs for rare diseases.
Halaven is marketed by Eisai based in Woodcliff Lake, New Jersey.
Carrot Puree with Mint-Garlic Yogurt Sauce & Warm Pita
Taking carrots to a whole new level ©Joyce Hays, Target Health Inc.
2 pounds carrots, peeled and sliced
1 teaspoon cumin seeds, lightly toasted and ground
3/4 teaspoon caraway seeds, ground
1 teaspoon coriander
1 teaspoon cardamom
1 teaspoon black sesame seeds (toast them)
1 teaspoon black mustard seeds (toast them)
1/2 teaspoon chili flakes
Pinch Salt & black pepper (or to taste)
3 Tablespoons extra virgin olive oil
2 Tablespoons fresh lemon juice (to taste)
Chopping fresh mint leaves, for the yogurt sauce. ©Joyce Hays, Target Health Inc.
1/2 cup thick Greek style plain low-fat yogurt
3 garlic cloves, mashed to a puree with salt to taste with a fork or in a mortar and pestle
1 Tablespoon extra virgin olive oil
1 Tablespoon fresh lemon juice
1 Tablespoon finely chopped mint
Steam the carrots above 1 inch of boiling water for 15 minutes or until soft. Remove from the heat and transfer to a food processor.
Steaming the carrots ©Joyce Hays, Target Health Inc.
Pulse the carrots in the food processor and scrape down the sides of the bowl. Turn on the food processor and while the machine is running, pour in the olive oil and lemon juice. Process until the carrots are pureed. Stop the machine and scrape down the sides of the bowl with a spatula.
Toasting the cumin seeds, black sesame seeds & black mustard seeds together (in extra virgin olive oil). ©Joyce Hays, Target Health Inc.
Add the cumin seeds, caraway seeds, black sesame seeds, black mustard seeds, chili flakes, and all the other seasonings, and pinch salt, pinch black pepper and process until everything is well mixed. Taste and adjust seasonings.
Pulsing the carrots and adding rest of ingredients to food processor. ©Joyce Hays, Target Health Inc.
Scrape all the carrot puree out of the food processor, with a spatula, and put into a serving bowl.
Here all the ingredients for the yogurt sauce, have been added and mixed, except for the chopped mint leaves. ©Joyce Hays, Target Health Inc.
Seasoned yogurt: combine all of the ingredients and mix together until well combined. Make a well in the middle of the carrots and spoon in the seasoned yogurt.
Just before serving warm the carrots up in the microwave.
Transfer the carrot puree to a platter. Add the seasoned yogurt to the middle of the carrot puree, and warm pita bread around it.
In this photo, carrots are served as a warm dip with yogurt sauce and warm pita. ©Joyce Hays, Target Health Inc.
Serve the carrot puree as a warm or cold dip, with pita triangles, crudites; or as an appetizer with an assortment of breads and rolls. Or serve the carrot puree as a warm vegetable or side dish. Any way you serve it, you can’t go wrong. We like both.
I’ve been experimenting with interesting, delicious and colorful ways to prepare healthy vegetables. Some of our favorites are broccoli, cauliflower, zucchini, butternut squash and somehow I left out carrots. Carrots always seemed to be relegated to banal roles: crudit?s, stews, chicken soup, or some peripheral ingredient. Dunno exactly why. So, in this recipe, I am attempting to compensate for my lack of carrot creativity, by sharing with you my really yummy carrot recipe that is versatile. I’m using the spices for this carrot recipe, in many other recipes as well. We’ve developed a taste for all of these wonderful spices, so I tend to use some or all in many other creations. We now love my concoctions, using spices from the Middle East, Northern Africa and India. I have graduated to toasting seeds myself and grinding spices in a mortar & pestle; garlic is prepared in many ways: sliced, squeezed, minced, mashed, crushed and all are good.
We began this meal with chilled Pinot Grigio and black and green olives, plus one of our favorite salads, Ugli, which is Ugli, Beefsteak or Heirloom tomatoes cut up with avocado, freshly squeezed garlic, endive, thinly sliced cucumber circles, tiny green olives, all in a simple extra virgin olive oil/fresh lemon juice dressing. Next came another of my new recipes, salmon cakes, Japanese sweet potatoes with a parsley-garlic stuffing, and the carrot puree that you see, with toasted black mustard & sesame seeds. The salmon cakes had a simple dressing, and the carrot puree had a yogurt dressing, served with warm pita bread. I’ve been trying to create recipes for healthy fresh vegetables with spices that add a unique and wonderful taste. This was a dinner filled with fabulous flavors, and if I do say so myself, everything worked together very well. For dessert, we had an experimental pineapple bourbon upside down cake, which was delicious but didn’t look it (needs more experimentation).
This weekend we saw a brilliant production of Arthur Miller’s, View From the Bridge. We’ve always responded to the writing skills of Arthur Miller, but this production took genius to a whole new level. Whoever conceived of the idea to pare this play, down to the bare bone basic Greek allegorical (or Shakespearean) tragedy that it is, gave the audience a precious jewel of a play, and a theatrical experience, never to be forgotten.
If you love the arts, especially theater when it is superb, run to get tickets to this particular production. You will never see View From the Bridge, done this well again. BTW, you have to allow this production to grow on you. It took me 1 hour to get it. After that, I was overtaken with emotion. Miller feels compassion for all his characters and so does the audience, You will not leave the theater without a profound cathartic awareness of what it is to be human, the sorrow of it (a few laughs thrown in). You have our promise that you will not be disappointed. This is theater at its best!
An old standby, chilled Santa Margherita, Pinot Grigio. ©Joyce Hays, Target Health Inc.
From Our Table to Yours!
Findings could lead to non-toxic drugs that block diseases’ chemistry
January 28, 2016
University of Iowa
Chemists have revealed the chemistry behind how certain diseases, from anthrax to tuberculosis, replicate. The key lies in the function of a gene absent in humans, called thyX, and its ability to catalyze the DNA building block thymine. The finding could help drug companies target the chemical reaction, rather than testing millions of compounds, to stop these diseases.
Humans have been successful at treating a host of diseases. Yet some continue to elude medicine’s best attempts.
Tuberculosis killed 15 percent of the 9.6 million people who contracted it worldwide in 2014. Typhus has flared periodically throughout history, with deadly consequences. Rocky Mountain spotted fever is a tick-borne threat in North and South America. Pneumonia is common everywhere.
What unites these diseases is their ability to fend off antibiotics and continue to reproduce, through a mysterious molecular route that yields thymine, a DNA building block the bacteria need to survive and reproduce.
Now, researchers at the University of Iowa have revealed how these diseases replicate by tracing the precise steps through which they use a gene absent in humans, called thyX, to code an enzyme to produce thymine. In a paper published online Jan. 28 in the journal Science, the Iowa chemists break down each stage in a rapid-fire chain of chemical reactions showing how thyX and the enzyme it encodes are used in the diseases’ DNA-production cycle.
The discovery could lead to the creation of non-toxic antibiotics that block the chemical reaction involving thyX, rather than relying on the current method of testing millions of drug compounds in the hopes of finding one that would faithfully kill each disease.
“We know a lot about these pathogens, but we didn’t know how the enzyme with them is catalyzing the reactions for DNA synthesis–the chemistry behind it,” says Amnon Kohen, a chemistry professor at the UI and corresponding author on the paper. “Now, we’re showing at the molecular level, the principal steps by which the thyX-encoded enzyme catalyzes the production of thymine’s precursor, thymidylate.”
ThyX has lurked, undetected, for eons. Scientists first spotted the gene when they noticed that thermophilic bacteria–ancient organisms that live at very high temperatures and pressures around deep-ocean vents–were able to produce thymine even though they didn’t seem to have the genes to do it. In 2002, a research group in France pinpointed the heretofore mystery genes, and called them thyX. These new–or rather, ancient–genes seemed to produce thymine similar to the human gene thyA but had evolved separately.
No one knew why.
Kohen’s group dove deep into molecular chemistry to figure it out.
The team linked up with the UI’s Nuclear Magnetic Resonance facility to identify a critical intermediate of the reaction catalyzed by FDTS, an enzyme coded by thyX. When they compared that intermediate to those found in human enzymes, they found the paths to thymine were completely different. The human enzymes are encoded by folA and thyA genes, and their catalytic path involves a covalent bond activating one reactant, and direct chemistry between two reactants. The thyX-encoded FDTS, on the other hand, makes no bond with the reactant and conducts the chemistry through an enzymatic relay system (flavin).
“Actually, there are hardly any similarities between the classical mechanism found in humans and the newly discovered one,” Kohen says.
Several deadly diseases rely exclusively on thyX for survival and reproduction. Others, such as tuberculosis, can synthesize thymine with thyA or thyX, which makes them fiendishly difficult to eradicate because they can switch to another thymine pathway if one has been blocked. That explains why tuberculosis strains have become resistant to multiple drugs and thus difficult to contain.
Now that thyX’s role has been revealed, pharmaceutical companies can zero in on a product that gums up the cycle.
“Once it’s stuck, you’re dead in the water,” Kohen said.
Tatiana Mishanina, formerly with Kohen’s group and now at the University of Wisconsin-Madison, is the paper’s first author. Contributing authors are Liping Yu, director of the UI’s NMR facility, and members of Kohen’s group: Kalani Karunaratne, Dibyendu Mondal, John Corcoran, and Michael Choi.
The National Institutes of Health (grants R01 GM1 10775 and T32 GM008365) funded the study.
Here is a list of bacteria that use the gene thyX to replicate, and their associated diseases and conditions. Some also have a second pathway, using a gene found in humans–thyA–to reproduce.
Borrelia burgdorferi–Lyme disease
Helicobacter pylori–stomach ulcer, gastric cancer
Rickettsia rickettsii–Rocky Mountain spotted fever
- T. V. Mishanina, L. Yu, K. Karunaratne, D. Mondal, J. M. Corcoran, M. A. Choi, A. Kohen. An unprecedented mechanism of nucleotide methylation in organisms containing thyX. Science, 2016; 351 (6272): 507 DOI: 10.1126/science.aad0300
Source: University of Iowa. “Chemists uncover how key agent allows diseases to reproduce: Findings could lead to non-toxic drugs that block diseases’ chemistry.” ScienceDaily. ScienceDaily, 28 January 2016. <www.sciencedaily.com/releases/2016/01/160128151942.htm>.
January 28, 2016
Space Telescope Science Institute (STScI)
New Hubble telescope observations suggest that a high-velocity gas cloud was launched from the outer regions of our own galaxy around 70 million years ago. Now, the cloud is on a return collision course and is expected to plow into the Milky Way’s disk in about 30 million years. Astronomers believe it will ignite a spectacular burst of star formation then.
Hubble Space Telescope astronomers are finding that the old adage “what goes up must come down” even applies to an immense cloud of hydrogen gas outside our Milky Way galaxy. The invisible cloud is plummeting toward our galaxy at nearly 700,000 miles per hour.
Though hundreds of enormous, high-velocity gas clouds whiz around the outskirts of our galaxy, this so-called “Smith Cloud” is unique because its trajectory is well known. New Hubble observations suggest it was launched from the outer regions of the galactic disk, around 70 million years ago. The cloud was discovered in the early 1960s by doctoral astronomy student Gail Smith, who detected the radio waves emitted by its hydrogen.
The cloud is on a return collision course and is expected to plow into the Milky Way’s disk in about 30 million years. When it does, astronomers believe it will ignite a spectacular burst of star formation, perhaps providing enough gas to make 2 million suns.
“The cloud is an example of how the galaxy is changing with time,” explained team leader Andrew Fox of the Space Telescope Science Institute in Baltimore, Maryland. “It’s telling us that the Milky Way is a bubbling, very active place where gas can be thrown out of one part of the disk and then return back down into another.”
“Our galaxy is recycling its gas through clouds, the Smith Cloud being one example, and will form stars in different places than before. Hubble’s measurements of the Smith Cloud are helping us to visualize how active the disks of galaxies are,” Fox said.
Astronomers have measured this comet-shaped region of gas to be 11,000 light-years long and 2,500 light-years across. If the cloud could be seen in visible light, it would span the sky with an apparent diameter 30 times greater than the size of the full moon.
Astronomers long thought that the Smith Cloud might be a failed, starless galaxy, or gas falling into the Milky Way from intergalactic space. If either of these scenarios proved true, the cloud would contain mainly hydrogen and helium, not the heavier elements made by stars. But if it came from within the galaxy, it would contain more of the elements found within our sun.
The team used Hubble to measure the Smith Cloud’s chemical composition for the first time, to determine where it came from. They observed the ultraviolet light from the bright cores of three active galaxies that reside billions of light-years beyond the cloud. Using Hubble’s Cosmic Origins Spectrograph, they measured how this light filters through the cloud.
In particular, they looked for sulfur in the cloud which can absorb ultraviolet light. “By measuring sulfur, you can learn how enriched in sulfur atoms the cloud is compared to the sun,” Fox explained. Sulfur is a good gauge of how many heavier elements reside in the cloud.
The astronomers found that the Smith Cloud is as rich in sulfur as the Milky Way’s outer disk, a region about 40,000 light-years from the galaxy’s center (about 15,000 light-years farther out than our sun and solar system). This means that the Smith Cloud was enriched by material from stars. This would not happen if it were pristine hydrogen from outside the galaxy, or if it were the remnant of a failed galaxy devoid of stars. Instead, the cloud appears to have been ejected from within the Milky Way and is now boomeranging back.
Though this settles the mystery of the Smith Cloud’s origin, it raises new questions: How did the cloud get to where it is now? What calamitous event could have catapulted it from the Milky Way’s disk, and how did it remain intact? Could it be a region of dark matter — an invisible form of matter — that passed through the disk and captured Milky Way gas? The answers may be found in future research.
- Andrew J. Fox, Nicolas Lehner, Felix J. Lockman, Bart P. Wakker, Alex S. Hill, Fabian Heitsch, David V. Stark, Kathleen A. Barger, Kenneth R. Sembach, Mubdi Rahman. ON THE METALLICITY AND ORIGIN OF THE SMITH HIGH-VELOCITY CLOUD. The Astrophysical Journal, 2015; 816 (1): L11 DOI: 10.3847/2041-8205/816/1/L11
Source: Space Telescope Science Institute (STScI). “Monstrous cloud boomerangs back to our galaxy.” ScienceDaily. ScienceDaily, 28 January 2016. <www.sciencedaily.com/releases/2016/01/160128155751.htm>.
First observational evidence for assembly bias could impact understanding of the universe
January 25, 2016
Carnegie Mellon University
An international team of researchers has shown that the relationship between galaxy clusters and their surrounding dark matter halo is more complex than previously thought. The researchers’ findings are the first to use observational data to show that, in addition to mass, a galaxy cluster’s formation history plays a role in how it interacts with its environment.
An international team of researchers, including Carnegie Mellon University’s Rachel Mandelbaum, has shown that the relationship between galaxy clusters and their surrounding dark matter halo is more complex than previously thought. The researchers’ findings, published in Physical Review Letters today (Jan. 25), are the first to use observational data to show that, in addition to mass, a galaxy cluster’s formation history plays a role in how it interacts with its environment.
There is a connection between galaxy clusters and their dark matter halos that holds a great deal of information about the universe’s content of dark matter and accelerating expansion due to dark energy. Galaxy clusters are groupings of hundreds to thousands of galaxies bound together by gravity, and are the most massive structures found in the universe. These clusters are embedded in a halo of invisible dark matter. Traditionally, cosmologists have predicted and interpreted clustering by calculating just the masses of the clusters and their halos. However, theoretical studies and cosmological simulations suggested that mass is not the only element at play — something called assembly bias, which takes into account when and how a galaxy cluster formed, also could impact clustering.
“Simulations have shown us that assembly bias should be part of our picture,” said Mandelbaum, a member of Carnegie Mellon’s McWilliams Center for Cosmology. “Confirming this observationally is an important piece of understanding galaxy and galaxy cluster formation and evolution.”
In the current study, the research team, led by Hironao Miyatake, Surhud More and Masahiro Takada of the Kavli Institute for the Physics and Mathematics of the Universe, analyzed observational data from the Sloan Digital Sky Survey’s DR8 galaxy catalog. Using this data, they demonstrated that when and where galaxies group together within a cluster impacts the cluster’s relationship with its dark matter environment.
The researchers divided close to 9,000 galaxy clusters into two groups based on the spatial distribution of the galaxies in each cluster. One group consisted of clusters with galaxies aggregated at the center and the other consisted of clusters in which the galaxies were more diffuse. They then used a technique called gravitational lensing to show that, while the two groups of clusters had the same mass, they interacted with their environment much differently. The group of clusters with diffuse galaxies were much more clumpy than the group of clusters that had their galaxies close to the center.
“Measuring the way galaxy clusters clump together on large scales is a linchpin of modern cosmology. We can go forward knowing that mass might not be the only factor in clustering,” Mandelbaum said.
- Hironao Miyatake, Surhud More, Masahiro Takada, David N. Spergel, Rachel Mandelbaum, Eli S. Rykoff, and Eduardo Rozo. Evidence of Halo Assembly Bias in Massive Clusters. Phys. Rev. Lett., 25 January 2016 DOI: 10.1103/PhysRevLett.116.041301
Source: Carnegie Mellon University. “In galaxy clustering, mass may not be the only thing that matters: First observational evidence for assembly bias could impact understanding of the universe.” ScienceDaily. ScienceDaily, 25 January 2016. <www.sciencedaily.com/releases/2016/01/160125114233.htm>.
Newly discovered star offers opportunity to explore origins of first stars sprung to life in early universe
January 22, 2016
University of Notre Dame
A team of researchers has observed the brightest ultra metal-poor star ever discovered. The star is a rare relic from the Milky Way’s formative years. As such, it offers astronomers a precious opportunity to explore the origin of the first stars that sprung to life within our galaxy and the universe.
A team of researchers has observed the brightest ultra metal-poor star ever discovered.
The star is a rare relic from the Milky Way’s formative years. As such, it offers astronomers a precious opportunity to explore the origin of the first stars that sprung to life within our galaxy and the universe.
A Brazilian-American team including Vinicius Placco, a research assistant professor at the University of Notre Dame and a member of JINA-CEE (Joint Institute for Nuclear Astrophysics — Center for the Evolution of the Elements), and led by Jorge Meléndez from the University of São Paulo used two of European Southern Observatory’s telescopes in Chile to discover this star, named 2MASS J18082002-5104378.
The star was spotted in 2014 using ESO’s New Technology Telescope. Follow-up observations using ESO’s Very Large Telescope discovered that, unlike younger stars such as the sun, this star shows an unusually low abundance of what astronomers call metals — elements heavier than hydrogen and helium. It is so devoid of these elements that it is known as an ultra metal-poor star.
Although thought to be ubiquitous in the early universe, metal-poor stars are now a rare sight within both the Milky Way and other nearby galaxies. Metals are formed during nuclear fusion within stars, and are spread throughout the interstellar medium when some of these stars grow old and explode. Subsequent generations of stars therefore form from increasingly metal-rich material. Metal-poor stars, however, formed from the unpolluted environment that existed shortly after the Big Bang. Exploring stars such as 2MASS J18082002-5104378 may unlock secrets about their formation, and show what the universe was like at its very beginning.
- Jorge Meléndez, Vinicius M. Placco, Marcelo Tucci-Maia, Iván Ramírez, Ting S. Li, Gabriel Perez. 2MASS J18082002−5104378: The brightest (V= 11.9) ultra metal-poor star. Astronomy & Astrophysics, 2016; 585: L5 DOI: 10.1051/0004-6361/201527456
Source: University of Notre Dame. “Newly discovered star offers opportunity to explore origins of first stars sprung to life in early universe.” ScienceDaily. ScienceDaily, 22 January 2016. <www.sciencedaily.com/releases/2016/01/160122144733.htm>.
Cultural Liaison at Target Health
One way Target Health gives back to New York City for being one of the greatest city in the world is to sponsor many theatre clubs, the Metropolitan Opera and membership in the Nippon Club. CEO Joyce Hays has assigned Mui Ying Kwan as Cultural Liaison at Target Health. Mui Ying has been at Target Health for over 10 years and is a member of our clinical research department. In the capacity of, Cultural Liaison, Mui Ying will work closely with Joyce Hays to represent Target Health at cultural events. Mui Ying had a similar position when attending the New School. She was in a fellowship that collaborated with IDEO where she worked on cultural and educational design innovation projects for two semesters. IDEO is an award-winning global design firm that takes a human-centered, design-based approach to helping organizations in the public and private sectors innovate and grow..
View From the Upper East Side – Snow Storm Paralyzes the East Coast
With climate change, tornados hit Florida last week and this week the snow blanketed the East Coast of the US. This is a view of the Upper East Side of Manhattan the morning after. The drift below is at least 10 feet high.
View From the Upper East Side. ©Jules Mitchel, Target Health Inc.
ON TARGET is the newsletter of Target Health Inc., a NYC – based, full – service, contract research organization (eCRO), providing strategic planning, regulatory affairs, clinical research, data management, biostatistics, medical writing and software services to the pharmaceutical and device industries, including the paperless clinical trial.
For more information about Target Health contact Warren Pearlson (212 – 681 – 2100 ext. 104). For additional information about software tools for paperless clinical trials, please also feel free to contact Dr. Jules T. Mitchel or Ms. Joyce Hays. The Target Health software tools are designed to partner with both CROs and Sponsors. Please visit the Target Health Website.
Joyce Hays, Founder and Editor in Chief of On Target
Jules Mitchel, Editor
Triglyceride/HDL Ratio Predicts Heart Attacks, Diabetes
The American Heart Association recommends all adults over age 20 should have their cholesterol levels checked every four to six years. Cholesterol screening is done with a blood test that measures your levels of high-density lipoprotein (HDL) cholesterol (good cholesterol), low-density lipoprotein (LDL) cholesterol (bad cholesterol), and triglycerides. Most of the cholesterol in our bloodstream (75%) is produced by the liver, and the remaining 25% comes from the foods we eat. We all know that elevated blood cholesterol levels are not good for your health, but the right levels of cholesterol actually play a vital role in maintaining cell membranes and synthesizing hormones. The Centers for Disease Control reports that one-third of adults have high cholesterol levels.
A triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituent of body 1) ___ in humans and animals, as well as vegetable fat. They are also present in the blood to enable the bidirectional transference of adipose fat and blood glucose from the liver, and are a major component of human skin oils. There are many different types of triglyceride, with the main division being between saturated and unsaturated types. Saturated fats are saturated with hydrogen – all available places where hydrogen atoms could be bonded to carbon atoms are occupied. These have a higher melting point and are more likely to be solid at room temperature. 2) ___ fats have a lower melting point and are more likely to be liquid at room temperature.
Triglycerides cannot pass through cell membranes freely. Special enzymes on the walls of blood vessels called lipoprotein lipases must break down triglycerides into free fatty acids and glycerol. Fatty acids can then be taken up by cells via the fatty acid transporter (FAT). Triglycerides, play an important role in metabolism as energy sources and transporters of dietary fat. They contain more than twice as much 3) ___ as carbohydrates. In the human body, high levels of triglycerides in the bloodstream have been linked to atherosclerosis and, by extension, the risk of heart disease and 4) ___. However, the relative negative impact of raised levels of triglycerides compared to that of LDL:HDL ratios is as yet unknown. The risk can be partly accounted for by a strong inverse relationship between triglyceride level and HDL-cholesterol level.
Two blood tests that are done during routine physical exams can be used to predict whether you are at increased risk for a heart 5) ___(The Journal of Clinical Hypertension, Jan 13, 2016). It’s called the triglyceride/HDL ratio, calculated by dividing your triglycerides number by your HDL number.
Your triglycerides should be below 150 mg/dL (in Canada less than 1.7 mmol/L)
Your HDL cholesterol should be above 40 (in Canada, greater than 1.00 mmol/L)
Thus your Triglycerides/HDL ratio should be under 3.75
The triglycerides/HDL ratio also predicts risk for diabetes and pre-diabetes (J Investig Med, Feb 2014;62(2):345-9). Almost 50% of North American adults already have diabetes or 6) ___ (JAMA, September 8, 2015), diseases that damage every cell in your body to cause heart attacks, strokes, dementia, impotence, many cancers, blindness, deafness, and premature death. If your triglyceride/HDL ratio is above 3.75, you are at increased risk for pre-diabetes or diabetes. Check with your doctor. Since the majority of cases of diabetes are caused by a faulty lifestyle, not just by 7) ___, diabetes is both a preventable and curable disease with lifestyle changes. Many people with pre-diabetes and early diabetes can return to normal by changing their lifestyles long before they develop any symptoms of the disease.
Why Triglyceride/HDL Ratio Predicts Diabetes
Doctors screen for diabetes by ordering a fasting blood sugar. However, some people with pre-diabetes have normal fasting blood sugar levels. The first thing that happens when you start to become diabetic is that your blood sugar rises too high after you eat, even if your fasting blood sugar is normal. If your blood sugar is greater than 140 two hours after you eat, you are at least pre-diabetic, even if all your other tests are normal.
High Triglycerides: When your blood sugar rises too high, your liver converts the extra sugar into a fat called 8) ___, so an early sign of diabetes is a triglyceride level above 150 mg/dL (above 1.7 mmol/L in Canada).
Low HDL Cholesterol: High blood fat levels can cause clots and heart attacks, so you use your good HDL cholesterol to carry triglycerides from your bloodstream to your liver. A low HDL cholesterol is another early sign of diabetes.
Fatty Liver: Your HDL cholesterol carries extra fat from your bloodstream to your liver. Too much fat stored in your liver is called a fatty 9)___. Your liver is supposed to prevent blood sugar levels from rising too high. When blood sugar levels rise, the pancreas releases insulin which lowers high blood sugar levels by driving sugar from the bloodstream into the liver. However, if you have a fatty liver, it does not accept the 10) ___, so blood sugar levels remain high to cause diabetes.
You Can Check Your Own Triglyceride/HDL Ratio
Look at your most recent blood tests for your triglyceride and HDL cholesterol numbers. If your triglyceride/HDL ratio is greater than 3.75, you are likely to be at least pre-diabetic. If you can also pinch more than three inches of fat under the skin on your belly, you may already be diabetic. Check with your doctor. Realize that you cannot cure diabetes with drugs alone; you must change your lifestyle to prevent or cure diabetes:
2. Lose weight if overweight
3. Restrict foods and drinks with added sugars, fried foods, red meat and processed meats
4. Eat more fruits and vegetables
5. Get blood levels of hydroxy vitamin D above 50 nmol/L
Several nutritional supplements have been shown to be beneficial in improving cholesterol levels.
1. Fish oil can reduce triglycerides, and soy protein can slightly lower levels of LDL (bad) cholesterol and triglycerides and raise HDL (good) cholesterol.
2. Plant stanols and sterols naturally found in some fruits, vegetables, nuts, seeds, and legumes may help block absorption of cholesterol in the intestine.
3. Prescription nicotinic acid (niacin or vitamin B3) is often prescribed to improve cholesterol. Doses found in over-the-counter vitamin supplements are not sufficient to treat high cholesterol, and because of the potential for side effects, high doses should only be taken under a doctor’s supervision.
Note: Pre-diabetics and diabetics can have triglyceride/HDL ratios under 3.75. Your doctor will probably do additional tests for your diagnosis and treatment. A more dependable test is blood sugar taken two hours after you eat. If this is above 140, you are at least pre-diabetic. Sources: Gabe Mirkin MD; Wikipedia
ANSWERS: 1) fat; 2) Unsaturated; 3) energy; 4) stroke; 5) attack; 6) pre-diabetes; 7) genetics; 8) triglycerides; 9) liver; 10) sugar
Diabetes and Edward Albert Sharpey-Schafer MD (1850-1935)
Sir Edward Albert Sharpey-Shafer MD
Sir Edward Albert Sharpey-Schafer, an English physiologist and physician, is regarded as a founder of endocrinology. In 1894, together with George Oliver, he discovered and demonstrated the existence of adrenaline. He also coined the term endocrine for the secretions of the ductless glands. Schafer’s method of artificial respiration is named after him. Schafer also coined the word insulin after theorizing that a single substance from the pancreas was responsible for diabetes mellitus.
Sharpey-Schafer contributed greatly to the understanding diabetes, which has been affecting lives for thousands of years. An ailment suspected to be diabetes was recognized by the Egyptians in manuscripts dating to 1550 BCE. According to The National Medical Journal of India, ancient Indians (circa 600 BCE) were well aware of the condition. They tested for diabetes which they called sweet urine disease by determining if ants were attracted to a person’s urine. In Greek, diabetes means to pass through. Greek physicians named the disorder for its top symptom: the excessive passing of urine through the body’s system. Historical documents show that Greek, Indian, Persian, Chinese, Japanese, and Korean doctors were aware of the condition, but none could determine its cause. In earlier times, a diagnosis of diabetes was likely a death sentence.
Born Schafer, Edward was the third son of city merchant James William Henry Schafer who had been born in Hamburg but came to Britain as a young man, became a naturalized citizen and settled in Highgate, North London. Edward attended Clewer House School and then University College London in 1868 where he was taught by the physiologist William Sharpey and became the first Sharpey Scholar in 1873. He was appointed Assistant Professor of Practical Physiology in 1874 and was elected to the Royal Society in 1878 when he was only 28 years old. He was Fullerian Professor at the Royal Institution and became Jodrell Professor at UCL in 1883, a position he held until 1899 when he was appointed to the chair of physiology at the University of Edinburgh where he remained until his retirement in 1933 and becoming Emeritus Professor thereafter. His chair was filled by Prof Ivan De Burgh Daly.
Schafer was a founding member of the Physiological Society and from 1908 until 1933 edited the Quarterly Journal of Experimental Physiology. He was the recipient of many honorary degrees and prestigious medals both at home and abroad and his book on the Essentials of Histology ran to sixteen editions between 1885 and 1954. He introduced suprarenal extract (containing adrenaline as well as other active substances) into medicine. Schafer became a Fellow of the Royal Society in 1878, was president of the British Science Association in 1911-1912, was president of the British Medical Association in 1912. He was knighted in 1913.
Schafer was married twice, first to Maud Dixey and after her death in 1896, to Ethel Maud Roberts. There were four children by his first marriage, however, he outlived three of them: his eldest daughter died in 1905 and both his sons died in action in World War I. Following the death of his eldest son, John Sharpey Schafer, the name of ?Sharpey’, which had been given as a middle name, was prefixed by Schafer to his own surname in 1918, both in memory of his son and to perpetuate the name of his teacher, William Sharpey. His grandson, Edward Peter Sharpey-Schafer, was Professor of Medicine at St Thomas’ Hospital, London from 1948 until his death in 1963.
The American Diabetes Association (ADA) reported that in 1910, medical professionals took the first steps toward discovering a cause and treatment mode for diabetes. Edward Albert Sharpey-Shafer announced that the pancreas of a diabetes patient was unable to produce what he termed insulin, a chemical the body uses to break down sugar. Thus, excess sugar ended up in the urine. Physicians promoted a fasting diet combined with regular exercise to combat the disorder. Despite attempts to manage the disorder through diet and exercise, people with diabetes inevitably died prematurely. In 1921, scientists experimenting with dogs had a breakthrough in reversing the effects of diabetes. Two Canadian researchers Frederick Grant Banting and Charles Herbert Best successfully extracted insulin from healthy dogs. They then injected it into diabetic dogs to improve their condition.
Frederick Grant Banting and Charles Herbert Best
Although insulin injection began to successfully combat diabetes, some cases were unresponsive to this form of treatment. Harold Himsworth finally distinguished between the two types of diabetes in 1936, according to writings published by his son Richard in Diabetic Medicine. He defined them as insulin-sensitive and insulin-insensitive. Today, these classifications are commonly referred to as type 1 and type 2 diabetes. Type 2 diabetes was not treated successfully for many years. According to the ADA, oral medications were finally developed in the 1950s. These drugs helped sufferers of type 2 diabetes control their blood sugar levels by stimulating the pancreas to develop more insulin.
Large portable glucose meters were created in 1969, and have since been reduced to the size of a hand-held calculator. Portable glucose meters are a key tool in managing diabetes today. They allow you to monitor your blood sugar levels at home, at work, and anywhere else. Fairly simple to use, they produce accurate results. To learn more about glucose meters, click on this hot link. In 1970, insulin pumps were developed to mimic the body’s normal release of insulin. Today, these pumps are light and portable, allowing for comfortable wearing on a daily basis.
As recently as 20 years ago, type 2 diabetes was not observed to occur in children. In fact, it was once referred to as adult-onset diabetes and type 1 diabetes was called juvenile diabetes. However, more cases began appearing in children and teenagers in the past two decades due to poor eating habits, lack of exercise, and excess weight. As such, adult-onset diabetes was renamed type 2 diabetes. In the 1960’s, diabetes management improved significantly. The development of urine strips made detecting sugar easier and simplified the process of managing blood sugar levels, the Mayo Clinic reports. Introduction of the single-use syringe allowed for faster and easier insulin therapy options. Sugary drinks put anyone at risk. According to an international review of existing research, drinking too many sugary drinks – including soda and fruit juice – is positively associated with type 2 diabetes, regardless of weight. Researchers found that these drinks contribute to between 4-13% of type 2 diabetes cases in the United States.
Despite the medical strides made since diabetes was first described in ancient times, it still remains a major cause of death and health complications throughout the world. As of 2011, diabetes was the seventh-leading cause of death in the United States, according to the National Diabetes Information Clearinghouse. Now that blood sugar can be tested at home, diabetes is more manageable than ever. Insulin remains the primary treatment for type 1 diabetes. Those with type 2 diabetes can reduce their risk of health complications through regular exercise, healthy diets, and other medications. As we continue to increase our understanding of type 2 diabetes, new and more effective treatments and prevention methods will emerge. DNP, or 2,4-Dinitrophenol, is a controversial chemical with potentially toxic side effects. While it’s been labeled not fit for human consumption by regulatory boards in both the United States and the U.K., it remains widely available in supplement form. While dangerous in large quantities, a recent study considered the possibility that a controlled-release version of DNP could reverse diabetes in rats. This was because it has been successful in previous laboratory treatment of nonalcoholic fatty liver disease and insulin resistance, which is a precursor to diabetes. The controlled-release version, called CRMP, was found to not be toxic to rats, and the researchers posited that it could be safe and effective in controlling diabetes in humans.