Oskar Hertwig, Developmental Biologist

Oskar Hertwig: Photo credit: Erik Nordenskiold, The history of biology: a survey. Knopf, New York, 1935, S. 594. Online: archive.org, Public Domain, https://commons.wikimedia.org/w/index.php?curid=1020140

 

Oscar Hertwig (21 April 1849 – 25 October 1922) was a German zoologist and professor, who also wrote about the theory of evolution circa 1916, over 55 years after Charles Darwin’s book The Origin of Species. He was the elder brother of zoologist-professor Richard Hertwig (1850-1937). The Hertwig brothers were the most eminent scholars of Ernst Haeckel (and Carl Gegenbaur) from the University of Jena. They were independent of Haeckel’s philosophical speculations but took his ideas in a positive way to widen their concepts in zoology. Initially, between 1879-1883, they performed embryological studies, especially on the theory of the coelom (1881), the fluid-filled body cavity. These problems were based on the phylogenetic theorems of Haeckel, i.e. the biogenic theory (German = biogenetisches Grundgesetz), and the “gastraea theory”.

 

Within 10 years, the two brothers moved apart to the north and south of Germany. Oscar Hertwig later became a professor of anatomy in 1888 in Berlin; however, Richard Hertwig had moved 3 years prior, becoming a professor of zoology in Munich from 1885-1925, at Ludwig Maximilians Universitat, where he served the last 40 years of his 50-year career as a professor at 4 universities. Richard’s research focused on protists (the relationship between the nucleus and the plasm = “Kern-Plasma-Relation”), as well as on developmental physiological studies on sea urchins and frogs. He also wrote a leading Zoology textbook. He also discovered mitosis and meiosis.

 

Oscar Hertwig was a leader in the field of comparative and causal animal-developmental history. He also wrote a leading textbook. By studying sea urchins he proved that fertilization occurs due to the fusion of a sperm and egg cell. He recognized the role of the cell nucleus during inheritance and chromosome reduction during meiosis: in 1876, he published his findings that fertilization includes the penetration of a spermatozoon into an egg cell. Oscar Hertwig experiments with frog eggs revealed the ‘long axis rule’, or Hertwig rule. According to this rule cell divides along its long axis (1884). In 1885 Oscar wrote that nuclein (later called nucleic acid) is the substance responsible not only for fertilization but also for the transmission of hereditary characteristics. This early suggestion was proven correct much later in 1944 by the Avery – MacLeod – McCarty experiment which showed that this is indeed the role of the nucleic acid DNA. While Oscar was interested in developmental biology, he was opposed to chance as assumed in Charles Darwin?s theory. His most important theoretical book was: “Das Werden der Organismen, eine Widerlegung der Darwinschen Zufallslehre” (Jena, 1916) (translation: “The Origin of Organisms – a Refutation of Darwin’s Theory of Chance”).

 

Hertwig was elected a member of the Royal Swedish Academy of Sciences in 1903. Oscar Hertwig is known as Oscar Hedwig in the book “Who discovered what when” by David Ellyard. A history of the discovery of fertilization for mammals including scientists like Hertwig and other workers is given by the book “The Mammalian Egg” by Austin.

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