Thomas Willis MD (1621-1625), Father of Neuroscience

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Thomas Willis (27 January 1621 – 11 November 1675) was an English doctor who played an important part in the history of anatomy, neurology and psychiatry. He was a founding member of the Royal Society and is often called the father of neuroscience. Willis was born on his parents’ farm in Great Bedwyn, Wiltshire, where his father held the stewardship of the Manor. He was a kinsman of the Willys baronets of Fen Ditton, Cambridgeshire. At Oxford University he did a Bachelors degree, and Masters degree. Once qualified with a B. Med. in 1646, he began as an active physician by regularly attending the market at Abingdon.

 

Willis obtained his medical degree from Christ Church, Oxford. While at Oxford, he became Sedleian Professor of Natural History in 1660, and retained that position until his death. He did much experimental work with his associate Richard Lower. He performed injection experiments on cadavers and noted that if he injected the carotid artery on one side, the dye solution would come forth from the carotid on the opposite side.

 

He maintained an Anglican position; an Anglican congregation met at his lodgings in the 1650s, including John Fell, John Dolben, and Richard Allestree. Fell’s father Samuel Fell had been expelled as Dean of Christ Church, in 1647; Willis married Samuel Fell’s daughter Mary, and brother-in-law John Fell would later be his biographer. He employed Robert Hooke as an assistant, in the period 1656-58; this probably was another Fell family connection, since Samuel Fell knew Hooke’s father in Freshwater, Isle of Wight.

 

In 1664 Willis published his monumental work Cerebri Anatome, the most complete and accurate account of the nervous system that had hitherto appeared. In it he contributed the term “neurology“ to medicine, a word derived from the Greek, meaning “sinew,“ “tendon,“ or “bowstring.“ The word was translated and introduced into the English language in 1681 in Samuel Pordage’s translation of Willis’ work. Cerebri Anatome contains a classification of the cerebral nerves, the first description of the eleventh nerve, and a description of the hexagonal network of arteries at the base of the brain that we know as the circle of Willis. Although others had described the circle before Willis, he was the first to grasp its physiological and pathological significance. He records the clinical histories of two patients in whom he suggests that the anatomic configuration of the arteries at the base of the brain could prevent apoplexy. The book was illustrated by Christopher Wren, an associate of Willis at Oxford, later to become England’s leading architect and designer of St Paul’s Cathedral, numerous other English churches, and many historic secular buildings.

 

Willis moved to London in 1666 where he continued his careful clinical observations and made a number of other important contributions. He was the first to recognize that lesions in the region of the internal capsule will produce hemiplegia. He was the first (after the ancient Greeks and Romans) to notice the characteristic sweetish taste of diabetic urine. He described myasthenia gravis. He gave the first account of epidemic typhoid fever and typhus. He was the first to describe and name puerperal fever. He described the phenomenon of Willis’ paracusis: a deaf person who can hear only in the presence of noise.

 

One of several Oxford cliques of those interested in science grew up around Willis and Christ Church. Besides Hooke, others in the group were Nathaniel Hodges, John Locke, Richard Lower, Henry Stubbe and John Ward. (Locke went on to study with Thomas Sydenham, who would become Willis’s leading rival, and who both politically and medically held some incompatible views.) In the broader Oxford scene, he was a colleague in the “Oxford Club“ of experimentalists with Ralph Bathurst, Robert Boyle, William Petty, John Wilkins and Christopher Wren. Willis was on close terms with Wren’s sister Susan Holder, skilled in the healing of wounds.

 

In 1656 and 1659, Willis published two significant medical works, De Fermentatione and De Febribus. These were followed by the 1664 volume on the brain, which was a record of collaborative experimental work. From 1660 until his death, he was Sedleian Professor of Natural Philosophy at Oxford.

 

At the time of the formation of the Royal Society of London, he was on the 1660 list of priority candidates, and became a Fellow in 1661. Henry Stubbe became a polemical opponent of the Society, and used his knowledge of Willis’s earlier work before 1660 to belittle some of the claims made by its proponents. Willis later worked as a physician in Westminster, London, this coming about after he treated Gilbert Sheldon in 1666. He had a successful medical practice, in which he applied both his understanding of anatomy and known remedies, attempting to integrate the two; he mixed both iatrochemical and mechanical views. Willis combined the physician’s expert anatomical sophistication with the fluent use of an interpretive apparatus that see-sawed between novelty and tradition, Galenism and Gassendist atomism, iatrochemistry and mechanism. Among his patients was the philosopher Anne Conway, whom he had intimate relations with, but although he was consulted, Willis failed to relieve her headaches.

 

Willis is mentioned in John Aubrey’s Brief Lives; their families became linked generations later through the marriage of Aubrey’s distant cousin Sir John Aubrey, 6th Baronet of Llantrithyd to Martha Catherine Carter, the grand-niece of Sir William Willys, 6th Baronet of Fen Ditton.

 

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Frontispiece to Thomas Willis’ 1663 book “Diatribae duae medico-philosophicae – quarum prior agit de fermentatione“, engraved and published by Gerbrandus Schagen in Amsterdam

 

His anatomy of the brain and nerves, as described in his Cerebri anatome of 1664, is minute and elaborate. This work coined the term neurology, and was not the result of his own personal and unaided exertions; he acknowledged his debt to Christopher Wren, who provided drawings, Thomas Millington, and his fellow anatomist Richard Lower. It abounds in new information, and presents an enormous contrast with the vaguer efforts of his predecessors. In 1667 he published Pathologicae cerebri, et nervosi generis specimen, an important work on the pathology and neurophysiology of the brain. In it he developed a new theory of the cause of epilepsy and other convulsive diseases, and contributed to the development of psychiatry. In 1672 he published the earliest English work on medical psychology, “Two Discourses concerning The Soul of Brutes, Which is that of the Vital and Sensitive of Man“. Willis could be seen as an early pioneer of the mind-brain supervenience claim, prominent in present day neuropsychiatry and philosophy of mind. Unfortunately, his enlightenment did not affect his treatment of patients, advocating in some cases to hit the patient over the head with sticks.

 

Willis was the first to number the cranial nerves in the order in which they are now usually enumerated by anatomists. He noted the parallel lines of the mesolobe (corpus callosum), afterwards minutely described by F?lix Vicq-d’Azyr. He seems to have recognized the communication of the convoluted surface of the brain and that between the lateral cavities beneath the fornix. He described the corpora striata and optic thalami; the four orbicular eminences, with the bridge, which he first named annular protuberance; and the white mammillary eminences, behind the infundibulum. In the cerebellum he remarks about the arborescent arrangement of the white and grey matter, and gives a good account of the internal carotids, and the communications which they make with the branches of the basilar artery.

 

He coined the term mellitus in diabetes mellitus. An old name for the condition is “Willis’s disease“. He observed what had been known for many centuries elsewhere, that the urine is sweet in patients (glycosuria). His observations on diabetes formed a chapter of Pharmaceutice rationalis (1674). Further research came from Johann Conrad Brunner, who had met Willis in London.

 

Willis’s work gained currency in France through the writings of Daniel Duncan. The philosopher Richard Cumberland quickly applied the findings on brain anatomy to argue a case against Thomas Hobbes’s view of the primacy of the passions.

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