ENDOCRINOLOGY

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Hair Analysis May Help Diagnose Cushing Syndrome

 

Cortisol is produced by the adrenal glands and helps to maintain blood pressure and heart function and to regulate blood sugar levels and the immune system. For most people, cortisol levels decrease at night. An elevated nighttime cortisol level in the blood is considered to be a key indicator of Cushing Syndrome, a rare and potentially fatal disorder in which the body overproduces the stress hormone cortisol. The high level of cortisol may result from a tumor of the pituitary or adrenal glands or as a side effect from certain medications. Symptoms of excess cortisol include obesity, high blood pressure, high blood sugar, high cholesterol levels, fatigue and depression. Although the condition can be cured, it can be fatal if it is not diagnosed and treated early. Diagnosing Cushing Syndrome is often difficult and time-consuming, requiring 24 hours to analyze blood and urine tests, brain imaging tests, and tissue samples from sinuses at the base of the skull.

 

According to an article published in Endocrine: International Journal of Basic and Clinical Endocrinology (9 February 2017), analyzing a hair sample may help with the diagnosis of Cushing Syndrome. The study found that measuring cortisol levels in hair samples tracked closely with standard techniques for diagnosing Cushing Syndrome. The study enrolled 30 patients with Cushing Syndrome and 6 patients who did not have the condition. The number of patients in the study was small, compared to studies of patients with more common disorders, because Cushing Syndrome is rare and it is difficult to recruit a large number of patients. Still, the authors believe their study is the largest of its kind to compare hair cortisol levels to diagnostic tests in Cushing patients.

 

The study participants provided hair samples divided into three equal segments. Results showed that the hair segments closest (proximal) to the scalp had the most cortisol. Compared to hair segments furthest away from the scalp, the cortisol content of the proximal segments correlated closely with tests for cortisol levels in the urine and in blood taken at night. According to the authors, while these finding are intriguing, further studies are needed to confirm the findings.

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