NeuroEngineer at MIT Media Lab

 

 

Technologies for controlling neural circuit dynamics (through early 2008)
Lentivirus production protocol for in vivo neural gene targeting Simple hardware platforms for bi-directional optical control of neurons and excitable cells Multiple-color optical activation, silencing, and desynchronization of neural activity (“optogenetics”),
with halorhodopsin (Halo, NpHR) and Channelrhodopsin-2 (ChR2)
Millisecond-timescale optical activation of neurons with ChR2 (“optogenetics”)  

OpenStim Noninvasive Brain Stimulator – open transcranial magnetic stimulation (TMS)

Classes Inventions
Neurotechnology Ventures MAS.883 / 9.455 / 15.128 / 20.454 (Fall 2008) Principles of Neuroengineering MAS.881 / 9.422 / 20.452 (Fall 2008) Medical devices, information technologies, and uses for physics

 


Task-specific neural mechanisms of memory encoding (1999-2006)

Selective engagement of plasticity mechanisms for motor memory storage Differential generalization of oppositely-directed learned changes Distributed plasticity for information encoding Mechanistic interaction of old and new encoded memories

The physics of computation, and the computation of physics (1995-2000)

3D mouse interface using electric fields and OpenGL Tabletop NMR quantum computing (Master’s thesis) FPGA-based RF tag reader (Master’s thesis) Tree-based machine learning for violin physics simulation Control software for the MIT ORCA autonomous submarine
MEMS accelerometer using quantum tunneling A physics-based animation engine

 

 

 

Ed Boyden On NeuroEngineering

 

 

 

About this talk

Ed Boyden shows how, by inserting genes for light-sensitive proteins into brain cells, he can selectively activate or de-activate specific neurons with fiber-optic implants. With this unprecedented level of control, he’s managed to cure mice of analogs of PTSD and certain forms of blindness. On the horizon: neural prosthetics.

Speaker Ed Boyden: Neuroengineer

 

 

At the MIT Media Lab, Ed Boyden leads the Synthetic Neurobiology Group, which invents technologies to reveal how cognition and emotion arise from brain networks — and to enable systematic repair of disorders such as epilepsy and PTSD.

Why you should listen to him:

Working with an extraordinary array of tools — from 3-D printers to lasers to flasks of algae — Ed Boyden is creating new brains. A pioneer in the field of optogenetics, he is the founder and principal investigator of the synthetic neurobiology group at MIT.

Using a combination of lasers and genetic engineering, he implants brains with optical fibers that allow him to activate special proteins in specific neurons and see their connections. In addition to helping create detailed maps of brain circuitry, the engineering of these cells has been used to cure blindness in mice, and could point the way to cures for Parkinsons or Alzheimers, or to ways of connecting to the brain via prosthetics.

“Boyden was borrowing genes from the algae he was holding in the green flask. If he succeeds, people will become part machine, and part algae too.”

Carl Zimmer, Scientific American

 

 

Synthetic Neurobiology Group

Ed Boyden, Ph.D., Principal Investigator

 

Welcome

Welcome to the website for the Synthetic Neurobiology Group. This webpage describes our mission, our lab members and their projects, our publications, protocols, and reagents, news about our work, our neuroengineering curriculum, and how to get involved.

Contact

Ed Boyden, Ph.D.
Benesse Career Development Professor
Leader, Synthetic Neurobiology Group
Associate Professor, MIT Media Lab
Joint Professor, MIT Dept. of Biological Engineering, MIT Dept. of Brain and Cognitive Sciences
Investigator, MIT McGovern Institute
Associate Member, MIT Picower Institute
Room E15-473B, 20 Ames St.
Cambridge, MA 02139
phone: (617) 324-3085 begin_of_the_skype_highlighting              (617) 324-3085      end_of_the_skype_highlighting
fax: (617) 253-6285
email: esb@media.mit.edu
web: http://syntheticneurobiology.org

Your brain mediates everything you sense, feel, think, and do — and acts as your ultimate ‘neuromedia’ interface to the world. A challenge for humanity is to understand the brain at a level of abstraction that enables us to engineer its function — repairing pathology, augmenting cognition, and revealing insights into the human condition.

We are inventing new tools for analyzing and engineering brain circuits. We are devising technologies for controlling specific neural circuit elements, to understand their causal contribution to normal and pathological neural computations. Our inventions include ‘optogenetic’ tools we developed for activation and silencing of neural circuits with light, and noninvasive devices using novel physical principles to control neural activity.

We are using our inventions to enable systematic approaches to neuroscience, revealing how entire neural circuits operate to generate behavior, and empowering new therapeutic strategies for neurological and psychiatric disorders. Our entrepreneurial approach to tackling clinically and philosophically important problems will hopefully yield a better understanding of the nature of human existence, and enable the ability to engineer improvements thereupon.

 

The Issue of Consciousness

Unlike a computer, the brain is made of thousands of different types of cell, and we don’t know how they work. We need to be able to turn the cells on and off to see how they cooperate to implement brain computations, and how they go awry in brain disorders. What we’re doing is making genetically encoded neurons that we can turn on and off with light. By shining light on these cells we can activate them and see what they do.

What brain functions will this allow you to study?
Scientists now have unprecedented abilities to perturb and record from the brain, and that’s allowing us to go after complex ideas like thought and memory. Our tools will help us parse out emotion, memory, attention and consciousness. Put psychology and neuroscience together with neuroengineering, and some of the biggest questions in neuroscience become tractable.

Tell us about your tools.
The core idea is to take molecules that sense light and convert it into electrical energy, and put them in neurons. We can take a given class of brain cells and develop a virus to deliver genes to these cells. Then we can shine light on these cells and activate them and see what they do.

Where do you get the light-sensitive molecules?
We mine the genomes of the world – fungi, plants, archaea, bacteria – looking for molecules that convert light into different kinds of energy. We’re finding stuff already that you could never have dreamed up. We’ve found several classes of molecules that can pump negative charge in or positive charge out of cells. That’s really powerful in terms of what it allows us to do.

Can this approach treat disease?
Imagine we have an epileptic brain and we want to quiet it down. We can put these molecules into cells, shine light on them and turn them off, using a technique called neural silencing. Turning off seizures is a “killer app” for this sort of thing because there’s no other way to turn off brain circuits transiently.

We can also, potentially, install light sensors onto the spare neurons in blind people, converting the spare neurons into a camera so they can send info to the brain. We’ve done this in mice.

Another condition we’re working on in mice is post-traumatic stress disorder. We use implants to stimulate brain regions with light and causally assess which cells are associated with which emotions and memories. This way we can find true clinical targets to treat the condition.

It sounds quite invasive.
If we want to drive light very precisely in the central nervous system then we need some kind of implant. We are working on an array of optical devices that can beam light into the brain itself in three dimensions. The width of one of these devices is something like one-eighth that of the deep brain stimulation electrodes used to treat Parkinson’s. We’re also working hard to try and do this wirelessly.

What other problems do you need to overcome?
We’re using molecules from other species – from algae, from archaebacteria and fungi – and we need to put these into human cells. One thing that could happen is that the cells could die if the immune system detects them as foreign.

So we’ve done the first preclinical study, working with primates (Neuron, DOI: 10.1016/j.neuron.2009.03.011). There doesn’t seem to be cell death or an active immune response, there don’t seem to be immune cells infiltrating the brain. All the classical responses we looked for, we couldn’t find.

I would be the first to admit this is early days, but given the potential power of ultra-precise activation and silencing of neurons in the very complex neural circuits of the brain, we’re very eager to pursue the science.

You majored in physics. What drew you to neuroscience?
We’ve got all these rules from physics about how the universe works, but how do we perceive? How do we think? How do we feel? We haven’t exactly got a lot of insight into that from knowing about quarks and leptons. We know about the building blocks of the universe, but knowing a lot about physics doesn’t help us understand the brain as a complex physical system – and that’s one of the outstanding problems of the 21st century.

You work a lot with mouse models. How are you going to get at problems like consciousness by working on animals?

Consciousness and free will are always going to be tricky to analyse in anything but a human, and it’s even tricky to analyse in humans. But there are people who are doing very clever things.

Scientists have recorded neurons in the motor regions of the human brain, and it turns out that there are neurons that fire almost a second before people are aware they want to make a decision. So maybe we can’t analyse free will and consciousness in the animal brain per se, but if people find neural signatures of free will or consciousness then we can go into the animal brain and perturb them and see what happens. Then we can start to get at causality.

Where do you see this going, long term?
There are two ways of looking at this. One, in the medium term, is the kind of synthetic neurobiology we work on now, in the sense of taking an intact human brain and fixing it. The other would be building brains from scratch, and that’s something we haven’t even really thought about. We don’t know enough about the brain to build one completely from scratch. But it’s good to reevaluate every five or 10 years.

To read the complete article, go to: http://www.newscientist.com/article/dn20204-the-brain-engineer-shining-a-light-on-consciousness.html?page=1