Dr Mitchel will again be consulting for NIH in the area of Drug Development and Regulatory Affairs. It is our way of giving back, as no one gets rich doing this, and to assure that awards are only given to highly qualified contractors. Target e*CRF® is currently being used in 2 NIH programs.

For more information, please contact Dr. Jules T. Mitchel or Joyce Hays. For new business opportunities, contact Dr. Jules T. Mitchel .

University of Alberta researchers may have found a way to reduce the amount of bad cholesterol and fatty acids that end up in the blood from food the body 1) ___, a key discovery that could lead to new drugs to treat and reverse the effects of Type 2 diabetes and heart disease related to obesity. In a series of recently published articles, Dr. Richard Lehner and his colleagues report they successfully decreased the level of LDL (low-density lipids), the so-called bad cholesterol, in the blood of mice and hamsters by manipulating a particular 2) ___. It’s well-known that eating too much fat and sugar and too little exercise will make you fat, and that obesity often leads to 3) ___ and heart disease. Lehner’s group studied the mechanisms behind this and how these metabolic 4) ___ work. The activity of an enzyme was discovered, that releases fatty acids, from fat cells and the 5) ___, into the blood. Then it was determined, how to inhibit this activity. Drugs called 6) ___ are used to lower LDL levels in patients, but do not treat obesity. What makes the U of A researchers’ findings noteworthy is their discovery of how to inhibit LDL and 7) ___, which are another form of fat in the blood and a leading risk in obesity-related Type 2 diabetes as well as heart disease. There is a substantial pharmacological interest in the enzymes that control triglycerides and 8) ___ metabolism in tissues. This unique discovery is an important scientific breakthrough, but one that requires further testing. It was noted that a pill would not be “a magic bullet.” People still need to make the right lifestyle choices by exercising. Adapted from materials provided by University of Alberta

ANSWERS: 1) metabolizes; 2) enzyme; 3) diabetes; 4) pathways; 5) liver; 6) statins; 7) triglycerides; 8) cholesterol